MULTIPRED2: A computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles
Identifieur interne : 001466 ( Main/Exploration ); précédent : 001465; suivant : 001467MULTIPRED2: A computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles
Auteurs : Guang Lan Zhang [États-Unis] ; David S. Deluca [États-Unis] ; Derin B. Keskin [États-Unis] ; Lou Chitkushev [États-Unis] ; Tanya Zlateva [États-Unis] ; Ole Lund [Danemark] ; Ellis L. Reinherz [États-Unis] ; Vladimir Brusic [États-Unis]Source :
- Journal of Immunological Methods [ 0022-1759 ] ; 2010.
Abstract
MULTIPRED2 is a computational system for facile prediction of peptide binding to multiple alleles belonging to human leukocyte antigen (HLA) class I and class II DR molecules. It enables prediction of peptide binding to products of individual HLA alleles, combination of alleles, or HLA supertypes. NetMHCpan and NetMHCIIpan are used as prediction engines. The 13 HLA Class I supertypes are A1, A2, A3, A24, B7, B8, B27, B44, B58, B62, C1, and C4. The 13 HLA Class II DR supertypes are DR1, DR3, DR4, DR6, DR7, DR8, DR9, DR11, DR12, DR13, DR14, DR15, and DR16. In total, MULTIPRED2 enables prediction of peptide binding to 1077 variants representing 26 HLA supertypes. MULTIPRED2 has visualization modules for mapping promiscuous T-cell epitopes as well as those regions of high target concentration – referred to as T-cell epitope hotspots. Novel graphic representations are employed to display the predicted binding peptides and immunological hotspots in an intuitive manner and also to provide a global view of results as heat maps. Another function of MULTIPRED2, which has direct relevance to vaccine design, is the calculation of population coverage. Currently it calculates population coverage in five major groups in North America. MULTIPRED2 is an important tool to complement wet-lab experimental methods for identification of T-cell epitopes. It is available at
Url:
DOI: 10.1016/j.jim.2010.11.009
PubMed: 21130094
PubMed Central: 3090484
Affiliations:
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Deluca</name><affiliation wicri:level="2"><nlm:aff id="af0005">Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Keskin, Derin B" sort="Keskin, Derin B" uniqKey="Keskin D" first="Derin B." last="Keskin">Derin B. Keskin</name><affiliation wicri:level="2"><nlm:aff id="af0005">Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chitkushev, Lou" sort="Chitkushev, Lou" uniqKey="Chitkushev L" first="Lou" last="Chitkushev">Lou Chitkushev</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Computer Science, Metropolitan College, Boston University, Boston MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Computer Science, Metropolitan College, Boston University, Boston MA</wicri:regionArea><wicri:noRegion>Boston MA</wicri:noRegion></affiliation></author><author><name sortKey="Zlateva, Tanya" sort="Zlateva, Tanya" uniqKey="Zlateva T" first="Tanya" last="Zlateva">Tanya Zlateva</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Computer Science, Metropolitan College, Boston University, Boston MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Computer Science, Metropolitan College, Boston University, Boston MA</wicri:regionArea><wicri:noRegion>Boston MA</wicri:noRegion></affiliation></author><author><name sortKey="Lund, Ole" sort="Lund, Ole" uniqKey="Lund O" first="Ole" last="Lund">Ole Lund</name><affiliation wicri:level="1"><nlm:aff id="af0015">Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby</wicri:regionArea><wicri:noRegion>Lyngby</wicri:noRegion></affiliation></author><author><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L." last="Reinherz">Ellis L. Reinherz</name><affiliation wicri:level="2"><nlm:aff id="af0005">Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Brusic, Vladimir" sort="Brusic, Vladimir" uniqKey="Brusic V" first="Vladimir" last="Brusic">Vladimir Brusic</name><affiliation wicri:level="2"><nlm:aff id="af0005">Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Immunological Methods</title><idno type="ISSN">0022-1759</idno><idno type="eISSN">1872-7905</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>MULTIPRED2 is a computational system for facile prediction of peptide binding to multiple alleles belonging to human leukocyte antigen (HLA) class I and class II DR molecules. It enables prediction of peptide binding to products of individual HLA alleles, combination of alleles, or HLA supertypes. NetMHCpan and NetMHCIIpan are used as prediction engines. The 13 HLA Class I supertypes are A1, A2, A3, A24, B7, B8, B27, B44, B58, B62, C1, and C4. The 13 HLA Class II DR supertypes are DR1, DR3, DR4, DR6, DR7, DR8, DR9, DR11, DR12, DR13, DR14, DR15, and DR16. In total, MULTIPRED2 enables prediction of peptide binding to 1077 variants representing 26 HLA supertypes. MULTIPRED2 has visualization modules for mapping promiscuous T-cell epitopes as well as those regions of high target concentration – referred to as T-cell epitope hotspots. Novel graphic representations are employed to display the predicted binding peptides and immunological hotspots in an intuitive manner and also to provide a global view of results as heat maps. Another function of MULTIPRED2, which has direct relevance to vaccine design, is the calculation of population coverage. Currently it calculates population coverage in five major groups in North America. MULTIPRED2 is an important tool to complement wet-lab experimental methods for identification of T-cell epitopes. It is available at <ext-link ext-link-type="uri" xlink:href="http://cvc.dfci.harvard.edu/multipred2/">http://cvc.dfci.harvard.edu/multipred2/</ext-link>.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bjorkman, P J" uniqKey="Bjorkman P">P.J. Bjorkman</name></author><author><name sortKey="Saper, M A" uniqKey="Saper M">M.A. Saper</name></author><author><name sortKey="Samraoui, B" uniqKey="Samraoui B">B. Samraoui</name></author><author><name sortKey="Bennett, W S" uniqKey="Bennett W">W.S. Bennett</name></author><author><name sortKey="Strominger, J L" uniqKey="Strominger J">J.L. Strominger</name></author><author><name sortKey="Wiley, D C" uniqKey="Wiley D">D.C. Wiley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, S A" uniqKey="Brown S">S.A. Brown</name></author><author><name sortKey="Stambas, J" uniqKey="Stambas J">J. Stambas</name></author><author><name sortKey="Zhan, X" uniqKey="Zhan X">X. Zhan</name></author><author><name sortKey="Slobod, K S" uniqKey="Slobod K">K.S. Slobod</name></author><author><name sortKey="Coleclough, C" uniqKey="Coleclough C">C. Coleclough</name></author><author><name sortKey="Zirkel, A" uniqKey="Zirkel A">A. Zirkel</name></author><author><name sortKey="Surman, S" uniqKey="Surman S">S. Surman</name></author><author><name sortKey="White, S W" uniqKey="White S">S.W. White</name></author><author><name sortKey="Doherty, P C" uniqKey="Doherty P">P.C. Doherty</name></author><author><name sortKey="Hurwitz, J L" uniqKey="Hurwitz J">J.L. Hurwitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, K" uniqKey="Cao K">K. Cao</name></author><author><name sortKey="Hollenbach, J" uniqKey="Hollenbach J">J. Hollenbach</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X. Shi</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W. Shi</name></author><author><name sortKey="Chopek, M" uniqKey="Chopek M">M. Chopek</name></author><author><name sortKey="Fernandez Vina, M A" uniqKey="Fernandez Vina M">M.A. Fernandez-Vina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dawson, D V" uniqKey="Dawson D">D.V. Dawson</name></author><author><name sortKey="Ozgur, M" uniqKey="Ozgur M">M. Ozgur</name></author><author><name sortKey="Sari, K" uniqKey="Sari K">K. Sari</name></author><author><name sortKey="Ghanayem, M" uniqKey="Ghanayem M">M. Ghanayem</name></author><author><name sortKey="Kostyu, D D" uniqKey="Kostyu D">D.D. Kostyu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Hoon, M J" uniqKey="De Hoon M">M.J. de Hoon</name></author><author><name sortKey="Imoto, S" uniqKey="Imoto S">S. Imoto</name></author><author><name sortKey="Nolan, J" uniqKey="Nolan J">J. Nolan</name></author><author><name sortKey="Miyano, S" uniqKey="Miyano S">S. Miyano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doytchinova, I A" uniqKey="Doytchinova I">I.A. Doytchinova</name></author><author><name sortKey="Guan, P" uniqKey="Guan P">P. Guan</name></author><author><name sortKey="Flower, D R" uniqKey="Flower D">D.R. Flower</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gowthaman, U" uniqKey="Gowthaman U">U. Gowthaman</name></author><author><name sortKey="Chodisetti, S B" uniqKey="Chodisetti S">S.B. Chodisetti</name></author><author><name sortKey="Parihar, P" uniqKey="Parihar P">P. Parihar</name></author><author><name sortKey="Agrewala, J N" uniqKey="Agrewala J">J.N. Agrewala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, V" uniqKey="Gupta V">V. Gupta</name></author><author><name sortKey="Tabiin, T" uniqKey="Tabiin T">T. Tabiin</name></author><author><name sortKey="Sun, K" uniqKey="Sun K">K. Sun</name></author><author><name sortKey="Chandrasekaran, A" uniqKey="Chandrasekaran A">A. Chandrasekaran</name></author><author><name sortKey="Anwar, A" uniqKey="Anwar A">A. Anwar</name></author><author><name sortKey="Yang, K" uniqKey="Yang K">K. Yang</name></author><author><name sortKey="Chikhlikar, P" uniqKey="Chikhlikar P">P. Chikhlikar</name></author><author><name sortKey="Salmon, J" uniqKey="Salmon J">J. Salmon</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V. Brusic</name></author><author><name sortKey="Marques, E" uniqKey="Marques E">E. Marques</name></author><author><name sortKey="Srinivasan, K N" uniqKey="Srinivasan K">K.N. Srinivasan</name></author><author><name sortKey="August, J T" uniqKey="August J">J.T. August</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heiny, A T" uniqKey="Heiny A">A.T. Heiny</name></author><author><name sortKey="Miotto, O" uniqKey="Miotto O">O. Miotto</name></author><author><name sortKey="Srinivasan, K N" uniqKey="Srinivasan K">K.N. Srinivasan</name></author><author><name sortKey="Khan, A M" uniqKey="Khan A">A.M. Khan</name></author><author><name sortKey="Zhang, G L" uniqKey="Zhang G">G.L. Zhang</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V. Brusic</name></author><author><name sortKey="Tan, T W" uniqKey="Tan T">T.W. Tan</name></author><author><name sortKey="August, J T" uniqKey="August J">J.T. August</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holdsworth, R" uniqKey="Holdsworth R">R. Holdsworth</name></author><author><name sortKey="Hurley, C K" uniqKey="Hurley C">C.K. Hurley</name></author><author><name sortKey="Marsh, S G" uniqKey="Marsh S">S.G. Marsh</name></author><author><name sortKey="Lau, M" uniqKey="Lau M">M. Lau</name></author><author><name sortKey="Noreen, H J" uniqKey="Noreen H">H.J. Noreen</name></author><author><name sortKey="Kempenich, J H" uniqKey="Kempenich J">J.H. Kempenich</name></author><author><name sortKey="Setterholm, M" uniqKey="Setterholm M">M. Setterholm</name></author><author><name sortKey="Maiers, M" uniqKey="Maiers M">M. Maiers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, S K" uniqKey="Kim S">S.K. Kim</name></author><author><name sortKey="Demars, R" uniqKey="Demars R">R. DeMars</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, H H" uniqKey="Lin H">H.H. Lin</name></author><author><name sortKey="Ray, S" uniqKey="Ray S">S. Ray</name></author><author><name sortKey="Tongchusak, S" uniqKey="Tongchusak S">S. Tongchusak</name></author><author><name sortKey="Reinherz, E L" uniqKey="Reinherz E">E.L. Reinherz</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V. Brusic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, H H" uniqKey="Lin H">H.H. Lin</name></author><author><name sortKey="Zhang, G L" uniqKey="Zhang G">G.L. Zhang</name></author><author><name sortKey="Tongchusak, S" uniqKey="Tongchusak S">S. Tongchusak</name></author><author><name sortKey="Reinherz, E L" uniqKey="Reinherz E">E.L. Reinherz</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V. Brusic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lund, O" uniqKey="Lund O">O. Lund</name></author><author><name sortKey="Nielsen, M" uniqKey="Nielsen M">M. Nielsen</name></author><author><name sortKey="Kesmir, C" uniqKey="Kesmir C">C. Kesmir</name></author><author><name sortKey="Petersen, A G" uniqKey="Petersen A">A.G. Petersen</name></author><author><name sortKey="Lundegaard, C" uniqKey="Lundegaard C">C. Lundegaard</name></author><author><name sortKey="Worning, P" uniqKey="Worning P">P. Worning</name></author><author><name sortKey="Sylvester Hvid, C" uniqKey="Sylvester Hvid C">C. Sylvester-Hvid</name></author><author><name sortKey="Lamberth, K" uniqKey="Lamberth K">K. Lamberth</name></author><author><name sortKey="Roder, G" uniqKey="Roder G">G. Roder</name></author><author><name sortKey="Justesen, S" uniqKey="Justesen S">S. Justesen</name></author><author><name sortKey="Buus, S" uniqKey="Buus S">S. Buus</name></author><author><name sortKey="Brunak, S" uniqKey="Brunak S">S. Brunak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lundegaard, C" uniqKey="Lundegaard C">C. Lundegaard</name></author><author><name sortKey="Lund, O" uniqKey="Lund O">O. Lund</name></author><author><name sortKey="Nielsen, M" uniqKey="Nielsen M">M. Nielsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meuer, S C" uniqKey="Meuer S">S.C. Meuer</name></author><author><name sortKey="Schlossman, S F" uniqKey="Schlossman S">S.F. Schlossman</name></author><author><name sortKey="Reinherz, E L" uniqKey="Reinherz E">E.L. Reinherz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nielsen, M" uniqKey="Nielsen M">M. Nielsen</name></author><author><name sortKey="Lundegaard, C" uniqKey="Lundegaard C">C. Lundegaard</name></author><author><name sortKey="Blicher, T" uniqKey="Blicher T">T. Blicher</name></author><author><name sortKey="Lamberth, K" uniqKey="Lamberth K">K. Lamberth</name></author><author><name sortKey="Harndahl, M" uniqKey="Harndahl M">M. Harndahl</name></author><author><name sortKey="Justesen, S" uniqKey="Justesen S">S. Justesen</name></author><author><name sortKey="Roder, G" uniqKey="Roder G">G. Roder</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B. Peters</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name></author><author><name sortKey="Lund, O" uniqKey="Lund O">O. Lund</name></author><author><name sortKey="Buus, S" uniqKey="Buus S">S. Buus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nielsen, M" uniqKey="Nielsen M">M. Nielsen</name></author><author><name sortKey="Lundegaard, C" uniqKey="Lundegaard C">C. Lundegaard</name></author><author><name sortKey="Blicher, T" uniqKey="Blicher T">T. Blicher</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B. Peters</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name></author><author><name sortKey="Justesen, S" uniqKey="Justesen S">S. Justesen</name></author><author><name sortKey="Buus, S" uniqKey="Buus S">S. Buus</name></author><author><name sortKey="Lund, O" uniqKey="Lund O">O. Lund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reche, P A" uniqKey="Reche P">P.A. Reche</name></author><author><name sortKey="Keskin, D B" uniqKey="Keskin D">D.B. Keskin</name></author><author><name sortKey="Hussey, R E" uniqKey="Hussey R">R.E. Hussey</name></author><author><name sortKey="Ancuta, P" uniqKey="Ancuta P">P. Ancuta</name></author><author><name sortKey="Gabuzda, D" uniqKey="Gabuzda D">D. Gabuzda</name></author><author><name sortKey="Reinherz, E L" uniqKey="Reinherz E">E.L. Reinherz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reche, P A" uniqKey="Reche P">P.A. Reche</name></author><author><name sortKey="Reinherz, E L" uniqKey="Reinherz E">E.L. Reinherz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reich, M" uniqKey="Reich M">M. Reich</name></author><author><name sortKey="Liefeld, T" uniqKey="Liefeld T">T. Liefeld</name></author><author><name sortKey="Gould, J" uniqKey="Gould J">J. Gould</name></author><author><name sortKey="Lerner, J" uniqKey="Lerner J">J. Lerner</name></author><author><name sortKey="Tamayo, P" uniqKey="Tamayo P">P. Tamayo</name></author><author><name sortKey="Mesirov, J P" uniqKey="Mesirov J">J.P. Mesirov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riemer, A B" uniqKey="Riemer A">A.B. Riemer</name></author><author><name sortKey="Keskin, D B" uniqKey="Keskin D">D.B. Keskin</name></author><author><name sortKey="Zhang, G" uniqKey="Zhang G">G. Zhang</name></author><author><name sortKey="Handley, M" uniqKey="Handley M">M. Handley</name></author><author><name sortKey="Anderson, K S" uniqKey="Anderson K">K.S. Anderson</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V. Brusic</name></author><author><name sortKey="Reinhold, B" uniqKey="Reinhold B">B. Reinhold</name></author><author><name sortKey="Reinherz, E L" uniqKey="Reinherz E">E.L. Reinherz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robinson, J" uniqKey="Robinson J">J. Robinson</name></author><author><name sortKey="Waller, M J" uniqKey="Waller M">M.J. Waller</name></author><author><name sortKey="Fail, S C" uniqKey="Fail S">S.C. Fail</name></author><author><name sortKey="Mcwilliam, H" uniqKey="Mcwilliam H">H. McWilliam</name></author><author><name sortKey="Lopez, R" uniqKey="Lopez R">R. Lopez</name></author><author><name sortKey="Parham, P" uniqKey="Parham P">P. Parham</name></author><author><name sortKey="Marsh, S G" uniqKey="Marsh S">S.G. Marsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name></author><author><name sortKey="Sidney, J" uniqKey="Sidney J">J. Sidney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sidney, J" uniqKey="Sidney J">J. Sidney</name></author><author><name sortKey="Grey, H M" uniqKey="Grey H">H.M. Grey</name></author><author><name sortKey="Kubo, R T" uniqKey="Kubo R">R.T. Kubo</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sidney, J" uniqKey="Sidney J">J. Sidney</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B. Peters</name></author><author><name sortKey="Frahm, N" uniqKey="Frahm N">N. Frahm</name></author><author><name sortKey="Brander, C" uniqKey="Brander C">C. Brander</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Surman, S" uniqKey="Surman S">S. Surman</name></author><author><name sortKey="Lockey, T D" uniqKey="Lockey T">T.D. Lockey</name></author><author><name sortKey="Slobod, K S" uniqKey="Slobod K">K.S. Slobod</name></author><author><name sortKey="Jones, B" uniqKey="Jones B">B. Jones</name></author><author><name sortKey="Riberdy, J M" uniqKey="Riberdy J">J.M. Riberdy</name></author><author><name sortKey="White, S W" uniqKey="White S">S.W. White</name></author><author><name sortKey="Doherty, P C" uniqKey="Doherty P">P.C. Doherty</name></author><author><name sortKey="Hurwitz, J L" uniqKey="Hurwitz J">J.L. Hurwitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J H" uniqKey="Wang J">J.H. Wang</name></author><author><name sortKey="Reinherz, E L" uniqKey="Reinherz E">E.L. Reinherz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, G L" uniqKey="Zhang G">G.L. Zhang</name></author><author><name sortKey="Bozic, I" uniqKey="Bozic I">I. Bozic</name></author><author><name sortKey="Kwoh, C K" uniqKey="Kwoh C">C.K. Kwoh</name></author><author><name sortKey="August, J T" uniqKey="August J">J.T. August</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V. Brusic</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, G L" uniqKey="Zhang G">G.L. Zhang</name></author><author><name sortKey="Khan, A M" uniqKey="Khan A">A.M. Khan</name></author><author><name sortKey="Srinivasan, K N" uniqKey="Srinivasan K">K.N. Srinivasan</name></author><author><name sortKey="August, J T" uniqKey="August J">J.T. August</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V. Brusic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, G L" uniqKey="Zhang G">G.L. Zhang</name></author><author><name sortKey="Khan, A M" uniqKey="Khan A">A.M. Khan</name></author><author><name sortKey="Srinivasan, K N" uniqKey="Srinivasan K">K.N. Srinivasan</name></author><author><name sortKey="Heiny, A" uniqKey="Heiny A">A. Heiny</name></author><author><name sortKey="Lee, K" uniqKey="Lee K">K. Lee</name></author><author><name sortKey="Kwoh, C K" uniqKey="Kwoh C">C.K. Kwoh</name></author><author><name sortKey="August, J T" uniqKey="August J">J.T. August</name></author><author><name sortKey="Brusic, V" uniqKey="Brusic V">V. Brusic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name></author><author><name sortKey="Lundegaard, C" uniqKey="Lundegaard C">C. Lundegaard</name></author><author><name sortKey="Nielsen, M" uniqKey="Nielsen M">M. Nielsen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Danemark</li><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Zhang, Guang Lan" sort="Zhang, Guang Lan" uniqKey="Zhang G" first="Guang Lan" last="Zhang">Guang Lan Zhang</name></region><name sortKey="Brusic, Vladimir" sort="Brusic, Vladimir" uniqKey="Brusic V" first="Vladimir" last="Brusic">Vladimir Brusic</name><name sortKey="Chitkushev, Lou" sort="Chitkushev, Lou" uniqKey="Chitkushev L" first="Lou" last="Chitkushev">Lou Chitkushev</name><name sortKey="Deluca, David S" sort="Deluca, David S" uniqKey="Deluca D" first="David S." last="Deluca">David S. Deluca</name><name sortKey="Keskin, Derin B" sort="Keskin, Derin B" uniqKey="Keskin D" first="Derin B." last="Keskin">Derin B. Keskin</name><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L." last="Reinherz">Ellis L. Reinherz</name><name sortKey="Zlateva, Tanya" sort="Zlateva, Tanya" uniqKey="Zlateva T" first="Tanya" last="Zlateva">Tanya Zlateva</name></country><country name="Danemark"><noRegion><name sortKey="Lund, Ole" sort="Lund, Ole" uniqKey="Lund O" first="Ole" last="Lund">Ole Lund</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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